All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know ALL.

The ALL Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

The ALL Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the ALL Hub cannot guarantee the accuracy of translated content. The ALL Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

Steering CommitteeAbout UsNewsletterContact
You're logged in! Click here any time to manage your account or log out.
You're logged in! Click here any time to manage your account or log out.

Blinatumomab in newly diagnosed adult patients with ALL in MRD negative remission: Results from ECON-ACRIN E1910

Jan 10, 2023
Learning objective: After reading this article, learners will be able to cite a new clinical development in acute lymphoblastic leukemia.

Bookmark this article


Adults with newly diagnosed acute lymphoblastic leukemia (ALL) achieve a high complete remission rate and measurable residual disease (MRD)-negative status with conventional chemotherapy; however, they often relapse post-induction and have suboptimal survival rates.1

Blinatumomab (blina), a bispecific T-cell engaging antibody that targets CD19, is Food and Drug Administration (FDA) approved for the treatment of children and adults with relapsed/refractory B-ALL and in morphologic complete response (CR) who are MRD positive (≥0.1).1

The ALL Hub has previously published the positive outcome of blina in patients with B-ALL and positive MRD at a minimum threshold of ≥10−4. Below, we report the preliminary results from the phase III ECOG-ACRIN E1910 study (NCT02003222) of blina consolidation in patients with newly diagnosed Philadelphia-negative B-ALL in MRD remission presented by Litzow, on behalf of the National Cooperative Clinical Trials Network, at the 64th American Society of Hematology (ASH) Annual Meeting and Exposition as a late-breaking abstract.1

Study design

This is an ongoing phase III study of consolidation chemotherapy with/without blina in patients with newly diagnosed Philadelphia-negative B-ALL. In total, 286 patients were randomized to blina + chemotherapy or chemotherapy alone. The study design is outlined in Figure 1.

Figure 1. Study design* 

blina, blinatumomab; chemo, chemotherapy; FDA, Food and Drug Administration; MRD, measurable residual disease.
*Adapted from Litzow, et al.
Following FDA approval of blina for MRD+ disease in March 2018, MRD+ patients were no longer randomized but assigned to arm C.

The objective of the study was to determine if patients who become MRD⁻ (<0.01%) after induction chemotherapy can have improved outcomes with the addition of blina to chemotherapy consolidation compared with patients who received chemotherapy alone.


  • Overall, 488 patients with a median age of 51 years (range, 30–70 years) were enrolled in Step 1 induction therapy.
  • In total, 224 MRD⁻ patients were randomized, with 112 patients in each arm and 22 patients in each arm proceeding to allogeneic bone marrow transplant.
  • The CR/CR with incomplete hematologic recovery (CRi) rate after induction chemotherapy was 81%; the CR rate was 75% and CRi rate was 6%.
  • In a third interim efficacy analysis of MRD⁻ patients, 17 patients in the blina arm and 39 in the control chemotherapy arm had died.
  • The upper limit for efficacy analysis was crossed in favor of blina with a significant improvement in overall survival for the blina arm (median OS, not reached vs 71.4 months; Hazard ratio, 0.42; 95% confidence interval [CI], 0.24–0.75; two-sided p = 0.003).
  • The median follow-up was 43 months and no significant safety signals were reported.


The addition of blina to consolidation chemotherapy has shown better survival outcomes vs chemotherapy alone in patients with newly diagnosed B-ALL who were MRD after intensification, with no new safety concerns reported. Based on these findings, the authors suggest that the addition of blina to consolidation chemotherapy represents a new standard of care for adult patients with MRDPhiladelphia-negative B-ALL.

  1. Litzow MR. Consolidation therapy with blinatumomab improves overall survival in newly diagnosed adult patients with B-lineage acute lymphoblastic leukemia in measurable residual disease negative remission: results from the ECOG-ACRIN E1910 randomized phase III National Cooperative Clinical Trials Network trial. Oral abstract #LBA-1. 64th American Society of Hematology Annual Meeting and Exposition. Dec 13, 2022; New Orleans, US.

Your opinion matters

Which of the following treatment options would you select for a patient with a high disease burden of relapsed/refractory Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia?
0 votes - 2 days left ...


Subscribe to get the best content related to ALL delivered to your inbox