Too much of a good thing? An in vitro study with dual Src/ABL kinase inhibitor and blinatumomab suggests some combination treatments for Ph+ ALL may not work well together

The most common cytogenic...

Novel concepts to target CD22 with CAR T-cell therapy for R/R B-ALL

Relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) is a difficult to treat disease with poor prognosis. Two...

Hyper-CVAD with sequential blinatumomab for the treatment of adult patients with newly diagnosed Philadelphia chromosome-negative B-cell ALL

Despite high rates of complete remissions, long-term...

Genetic markers in the prognosis of patients with ALL

Despite much research, the mutational landscape of patients with acute lymphoblastic leukemia (ALL) remains relatively poorly characterized,...

What are the major challenges for CAR T-cell therapies in Europe during the COVID-19 pandemic?

During the Virtual 47th Annual Meeting of the European Society for Blood and Marrow Transplantation...

What are the recent advances in immunotherapy for adult patients with ALL?

During the Acute Leukemia Forum (ALF) 2021, the ALL Hub spoke to Ibrahim T. Aldoss, City of Hope Comprehensive Cancer Center,...

Antibiotic treatment is associated with decreased response to CAR T-cell therapy

The health and diversity of the gut microbiome has been recognized to play a role in numerous health conditions. In...

Progress in immunotherapy for hematologic malignancies

Immunotherapy has long been part of the armamentarium of therapies for hematologic malignancies. One of the first applications of immunotherapy...

What are the major challenges for CAR T-cell therapies in Europe during the COVID-19 pandemic?

During the Virtual 47th Annual Meeting of the European Society for Blood and Marrow Transplantation...

Advances of cell therapies in China: Reducing manufacturing time with FasT dual CAR T-cells

The Multiple Myeloma Hub previously summarised activities on chimeric antigen receptor (CAR) T cells in...

Development of childhood B-ALL, triggering factors, and prospective treatments

Childhood B-cell acute lymphoblastic leukemia (B-ALL), also termed B-cell precursor ALL, is a malignant disease...

NCCN COVID-19 vaccination recommendations for patients with hematologic malignancies

Patients with cancer are at high risk of COVID-19-associated complications and, accordingly, the preliminary...