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During the 50th Annual Meeting of the EBMT, Balduzzi presented data from the prospective FORUM trial on the impact of minimal residual disease (MRD) at hematopoietic stem cell transplantation (HSCT) in children with B-cell acute lymphoblastic leukemia (B-ALL).1 Below, we summarize the key findings.
Figure 1. EFS, OS, CIR, and TRM by MRD status*‡
CIR, cumulative incidence of relapse; EFS, event-free survival; MRD, minimal residual disease; OS, overall survival; TRM, treatment-related mortality.
*Data from Balduzzi.1
†MRD-negative was defined as PCR MRD of 10-4 or MFC MRD of <0.01%.
‡MRD-positive was defined as PCR MRD of ≥ 10-4 or MFC MRD of ≥ 0.01%.
Figure 2. A 3-year EFS and B CIR by MRD status across conditioning regimens*
CIR, cumulative incidence of relapse; EFS, event-free survival; MRD, minimal residual disease; TBI, total body irradiation.
*Data from Balduzzi.1
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