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2024-07-16T11:41:01.000Z

Key considerations when preparing patients with ALL for CAR T-cell therapy

Jul 16, 2024
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Learning objective: After reading this article, learners will be able to cite a new clinical development in ALL

Key considerations when preparing patients with ALL for CAR T-cell therapy

During the ALL Hub Steering Committee meeting, André Baruchel chaired a discussion on “What are the key considerations when preparing patients with ALL for CAR T-cell therapy ?”, featuring Andrea Biondi, Anita Rijneveld, and José María Ribera. 

The discussion topics included: 

  • Key considerations when selecting patients: stable disease, degree of antigen expression, burden of bone marrow disease, and number of circulating tumor blasts 

  • Bridging therapy and lymphodepletion considerations 

  • The impact of prior exposure to blinatumomab and inotuzumab on CAR T-cell outcomes 

  • Indications for the use of tisagenlecleucel in pediatric ALL  

  • Indications for the use of brexucabtagene autoleucel in adult ALL 


Key considerations when preparing patients with ALL for CAR T-cell therapy

Your opinion matters

Which of the following treatment options would you prefer to use directly before CD19-directed CAR T-cell therapy in adult patients with Ph− R/R B-cell ALL?
2 votes - 4 days left ...

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