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Key considerations when preparing patients with ALL for CAR T-cell therapy
By Louise Niven
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Key considerations when preparing patients with ALL for CAR T-cell therapy
During the ALL Hub Steering Committee meeting, André Baruchel chaired a discussion on “What are the key considerations when preparing patients with ALL for CAR T-cell therapy ?”, featuring Andrea Biondi, Anita Rijneveld, and José María Ribera.
The discussion topics included:
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Key considerations when selecting patients: stable disease, degree of antigen expression, burden of bone marrow disease, and number of circulating tumor blasts
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Bridging therapy and lymphodepletion considerations
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The impact of prior exposure to blinatumomab and inotuzumab on CAR T-cell outcomes
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Indications for the use of tisagenlecleucel in pediatric ALL
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Indications for the use of brexucabtagene autoleucel in adult ALL
Key considerations when preparing patients with ALL for CAR T-cell therapy
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