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What are the current challenges in ALL that need to be addressed?

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Sep 24, 2020
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During the 2020 Annual Meeting of the Society of Hematologic Oncology (SOHO), the ALL Hub spoke to Selina M. Luger, University of Pennsylvania, Philadelphia, US. We asked: What are the current challenges in ALL that need to be addressed?

What are the current challenges in ALL that need to be addressed?

Here, she highlights a number of considerations regarding ALL treatment strategies:

1) Should all patients receive transplant for the treatment of ALL?

2) Do all patients with Philadelphia chromosome-positive ALL require intensive chemotherapy?

3) Are there patients with Philadelphia chromosome-negative ALL who demonstrate good responses without chemotherapy?

4) Should targeted agents be incorporated into chemotherapy regimens?

Selina M. Luger concludes by highlighting the lack of targeted agents available for T-cell ALL and outlines emerging therapeutics in this setting.