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2023-11-15T13:43:46.000Z

What is new in CAR T-cell therapy for pediatric acute lymphoblastic leukemia?

Nov 15, 2023
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Learning objective: After reading this article, learners will be able to cite a new clinical development in pediatric ALL.

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During the European Society of Hematology (ESH) 2nd How I manage: CAR T therapies and bispecific antibodies for my patients 2023 Congress, the Lymphoma Hub spoke to André Baruchel, Hôpital Robert-Debré, Paris, FR. We asked, What is new in chimeric antigen receptor (CAR) T-cell therapy for pediatric acute lymphoblastic leukemia.

What is new in CAR T-cell therapy for pediatric acute lymphoblastic leukemia?

Baruchel discusses long-term results of clinical trials investigating CAR T-cell therapy and the benefits for pediatric patients with advanced acute lymphoblastic leukemia. He also mentions potential causes for relapse after CAR T-cell treatment and how new constructs could tackle this problem.

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Which of the following treatment options would you select for a patient with a high disease burden of relapsed/refractory Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia?
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