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During the EHA 2022 Congress, we spoke with Jan Cools, VIB-KU Leuven Center for Cancer Biology, Leuven, BE. We asked, What is the cellular origin of acute lymphoblastic leukemia (ALL)?
What is the cellular origin of ALL?
Cools begins by discussing his current research into the genetic components of ALL development in adults. He outlines the accumulation of mutations in patients, including heterogeneity amongst patients and developments of leukemic cell mutations post-diagnosis. Cools goes on to discuss research into the cell-of-origin and how single-cell sequencing can provide further clarity. Finally, Cools highlights some insights on the genetic profile of T-cell ALL, particularly the order in which mutations occur in disease development.
The spleen as a site for residual disease in T-cell ALL
T-cell acute lymphoblastic leukemia (ALL) is highly aggressive and frequently spreads from the thymus to the bone marrow, liver, lymph nodes, and spleen among other areas. A subtype of T-cells...
Recurrent immature Ig gene rearrangements in TP53-mutated B-precursor adult ALL
During the premature stage of lymphopoiesis, immunoglobulin (Ig) and T-cell receptor (TCR) genes undergo rearrangements — key mechanisms of the physiological process....
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