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Blinatumomab in adult patients with MRD negative B-ALL: Interim results from the ECOG-ACRIN E1910 trial
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Results from the third interim efficacy analysis of the phase III ECOG-ACRIN E1910 trial (NCT02003222) evaluating blinatumomab in combination with standard consolidation chemotherapy in adult patients with BCR::ABL1 negative B-cell precursor acute lymphoblastic leukemia (B-ALL) in measurable residual disease (MRD) negative remission were published in The New England Journal of Medicine by Litzow et al.1
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| Key learnings |
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A total of 224 patients with BCR::ABL1-negative B-ALL in MRD negative remission were included in the analysis.
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At a median follow-up of 43 months, the 3-year overall survival was significantly improved in the blinatumomab group vs chemotherapy alone group (85% vs 68%; hazard ratio for death, 0.41; 95% confidence interval [CI]: 0.23–0.73; p = 0.002). |
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The 3-year relapse-free survival improved in the blinatumomab group vs chemotherapy alone group (80% vs 64%; hazard ratio for relapse or death, 0.53; 95% CI: 0.32–0.87). |
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The incidence of treatment-related Grade ≥3 neurologic or psychiatric adverse events was higher in the blinatumomab group vs chemotherapy alone group (23% vs 5%; p < 0.001). |
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The results suggest an overall survival benefit of the addition of blinatumomab to consolidation chemotherapy in adult patients with BCR::ABL1-negative B-ALL in MRD-negative remission; a longer international follow-up is needed to further confirm. |
- Litzow MR, Sun Z, Mattison RJ, et al. Blinatumomab for MRD-negative acute lymphoblastic leukemia in adults. N Engl J Med. 2024;391(4):320-333. DOI: 10.1056/NEJMoa2312948
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