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During the 48th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the ALL Hub spoke with Giovanna Lucchini, Great Ormond Street Hospital, London, UK. We asked, How does graft-versus-host disease (GvHD) affect outcomes for pediatric patients undergoing allogeneic stem cell transplantation (allo-SCT) for acute lymphoblastic leukemia (ALL)?
How does GvHD affect outcomes for pediatric patients undergoing allo-SCT for ALL?
Lucchini begins by describing how background disorders impact GvHD in patients post transplant. Lucchini then discusses the concept of engineering GvHD that is 'enough, but not too much' and highlights the need for more strategies to support patients and control GvHD.
HLA (mis)matching in haploidentical transplantation
To reduce the risk of graft-versus-host disease (GvHD) 8/8 human leukocyte antigen (HLA) matching is preferred, however the chance of finding a perfect match is low especially for some ethnic groups.
HLA-DPB1 mismatch models after unrelated donor stem cell transplantation
In a recent letter to Haematologica, Francesca Lorentino from the Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, IT, and...
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