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How effective is targeted therapy for Ph-like ALL?

During ESH 3rd How to Diagnose and Treat Acute Leukaemias the ALL Hub spoke with Emily Curran, University of Cincinnati, Cincinnati, US. We asked, How effective is targeted therapy for Ph-like ALL?

How effective is targeted therapy for Ph-like ALL?

Curran begins by outlining the Ph-like ALL subtype and current trial approaches, focusing on targets such as the ABL or JAK- targetable pathways. She discusses the results of some of this data in terms of clinical and pre-clinical models. Finally Curran discusses future studies, e.g. effectivity in less common Ph-like subtypes and the incorporation of novel immunotherapies like blinatumomab and Inotuzumab .