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Impact of leukemic molecular profile on the efficacy of inotuzumab ozogamicin in R/R ALL
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Results from the phase III INO-VATE (NCT01564784) trial evaluating the efficacy of inotuzumab ozogamicin (InO) for the treatment of relapsed/refractory acute lymphoblastic leukemia (R/R ALL) were published in Blood Advances by Zhao et al.1 Responses to InO were recorded in 91 patients by leukemic subtype, genomic alterations, and risk status.
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| Key learnings |
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The median overall survival was 7.7 months with InO compared with 6.2 months with standard of care (SoC) chemotherapy (hazard ratio, 0.75; p = 0.0105). |
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Patients with high-risk molecular profiles experienced improved complete remission (CR) and CR with incomplete hematologic recovery (CRi) rates with InO compared with SoC chemotherapy (74.7% vs 33.3%; p < 0.001).
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The CR rate in patients with TP53 alterations was also higher with InO compared with SoC chemotherapy (100% vs 12.5%; p = 0.0047). |
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The findings from the study suggest that InO may be a viable option for patients with R/R ALL, particularly those with high-risk molecular profiles, offering personalized treatment strategies. Further exploration of InO efficacy is needed in patients with BCR::ABL1-like subtype and TP53 alterations.
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- Zhao Y, Laird A, Roberts K, et al. Association of leukemic molecular profile with efficacy of inotuzumab ozogamicin in adults with relapsed/refractory ALL. Blood Advances. 2024;8(12):3226-3236. DOI: 1182/bloodadvances.2023012430
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