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During the 2023 European Hematology Association (EHA) Congress, the ALL Hub spoke to Fadi Haddad, MD Anderson Cancer Center, US. We asked, is mini-hyper-CVD plus venetoclax safe and effective in patients with relapsed/refractory (R/R) Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL)?
Is mini-hyper-CVD plus venetoclax safe and effective in patients with R/R Ph- ALL?
Haddad provided the rationale for this study by highlighting the synergistic effects and promising activity of the BCL2 inhibitor venetoclax plus chemotherapy in pre-clinical studies, as well as in patients with R/R ALL. This phase II trial included patients with R/R B-cell or T-cell ALL who received a median of two prior lines of therapy and had poor risk cytogenetics. Study endpoints included the safety profile, response rates, and survival outcomes.
Haddad concluded that mini-hyper-CVD plus venetoclax proved clinically effective and safe in patients with R/R Ph-ALL and, while it is not a definitive combination therapy, it could serve as a potential bridging therapy to stem cell transplantation or other therapies.
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