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Is mini-hyper-CVD plus venetoclax safe and effective in patients with R/R Ph- ALL?

Aug 25, 2023

Learning objective: After reading this article, learners will be able to cite new clinical developments in ALL.


During the 2023 European Hematology Association (EHA) Congress, the ALL Hub spoke to Fadi Haddad, MD Anderson Cancer Center, US. We asked, is mini-hyper-CVD plus venetoclax safe and effective in patients with relapsed/refractory (R/R) Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL)?

Is mini-hyper-CVD plus venetoclax safe and effective in patients with R/R Ph- ALL?

Haddad provided the rationale for this study by highlighting the synergistic effects and promising activity of the BCL2 inhibitor venetoclax plus chemotherapy in pre-clinical studies, as well as in patients with R/R ALL. This phase II trial included patients with R/R B-cell or T-cell ALL who received a median of two prior lines of therapy and had poor risk cytogenetics. Study endpoints included the safety profile, response rates, and survival outcomes.

Haddad concluded that mini-hyper-CVD plus venetoclax proved clinically effective and safe in patients with R/R Ph-ALL and, while it is not a definitive combination therapy, it could serve as a potential bridging therapy to stem cell transplantation or other therapies.

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