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What is the optimal use of asparaginase in adults with ALL?
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The ALL Hub spoke to Wendy Stock, The University of Chicago, Chicago, US. We asked, What is the optimal use of asparaginase in adults with acute lymphoblastic leukemia (ALL)?
What is the optimal use of asparaginase in adults with ALL?
Firstly, Stock reviews the data on the outcomes of intensive asparaginase-containing regimens for younger adults with ALL; while they significantly improved outcomes, issues remained around dosing, obesity, and associated toxicities. For the remainder of the discussion, Stock highlights treatment approaches to reduce toxicities in the adult population, including capping the dose of pegylated-asparaginase at 3,750 units and reducing the dose further.
Stock concludes by emphasizing the importance of asparaginase as a key component for young adults with ALL, with ongoing measures being investigated to mitigate toxicities. A study in North America is currently investigating the use of L-carnitine to reduce hepatoxicities.
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