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Charles G. Mullighan is a member of the Department of Pathology, deputy director at the Comprehensive Cancer Center, and co-leader of the Hematological Malignancies Program at St. Jude Children’s Research Hospital, Memphis, US. He is also the medical director at St. Jude Biorepository. Charles received his training in medicine, hematology, and hematopathology in Adelaide, AU, and undertook doctoral studies in immunogenetics at the University of Oxford, UK. His research interests include the use of integrated genomic and epigenomic approaches to understand the pathogenesis and evolution of ALL and related disorders; defining the interaction of inherited and somatic genetic alterations in leukemogenesis; the use of in vitro and in vivo experimental approaches to model genomic abnormalities in leukemogenesis; and preclinical therapeutic testing to translate genomic discoveries to new treatment approaches in ALL.