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Epigenetic modifier mutations

Epigenetic modifier mutations

Epigenetic modifiers alter the chromatin structure through posttranslational modifications, such as DNA methylation, thereby changing the accessibility to DNA and gene expression. Mutations in epigenetic regulators, such as DNMT3AIDH1IDH2TET2ASXL1EZH2, and MLL/KMT2A, are a key part of leukemogenesis. These mutations are believed to promote clonal outgrowth but require subsequent mutational events to initiate leukemic transformation.